Scienc-ome XR Innovation Hub (SXR) is a hackathon event in which we focus on producing anti-disciplinary science achieved by an international team, high-risk projects and research from various fields such as life science, physics, mathematics, engineering, and artificial intelligence. Our idea of SXR is based on the Human Frontier Science Program (HFSP) which is an international funding agency that has produced 28 Nobel Laureates in the past 30 years. HFSP funds a high-risk and interdisciplinary research project with a philosophy of “science without borders''. The alumni and current HFSP awardees join the operating committee in SXR. SXR employs a XR system defined as a “cross-reality” that offers a mixed environment of physical meeting and virtual reality (VR). The immersive technologies promote anti-disciplinary science by releasing temporal and spatial restrictions. SXR provides opportunities to build the relationship to the young scientists in universities and industries under the COVID-19 situations. We believe that anti-disciplinary science in SXR will provide a breakthrough in social changes leading to destructive innovations. The process of anti-disciplinary science through the hackathon would be a model for “crossing the border” and “disruption of temporal and spatial restrictions” by using XR.